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Name: Beta-cyclodextrin
Other name : β-cyclodextrin;cyclomaltoheptaose
Abbreviation : BCD
CAS No.: 7585-39-9
Molecular formula : C42H70O35
Molecular weight: 1134.98
Qaulity:Pharma grade / Food grade
Package: 500g/bag , 1kg/bag, 20kg/carton
Use : Medical Food,Chemical Agricultural, other industries
Standard: USP,CP
Formation mechanism of Beta-cyclodextrin inclusion complex
Because Beta-cyclodextrin has a special cavity structure, it can contain a variety of molecules with small polarities, and can form Beta-cyclodextrin packages. Among them, the coated substances are usually called "guests", and cyclodextrin is the "host". There are many types of cyclodextrins that can be coated with a wide range of objects, which can be inorganic ions, organic molecules, and even It is an inert gas. As long as the size of the guest molecule and the cavity of the host is appropriate, and the polarity of the molecule is smaller than that of water, it is possible to form clathrates. The formation of cyclodextrin inclusion compound is affected by internal and external factors. The internal influencing factors are mainly the basic properties of the subject and object, which can be summarized in the following three aspects:
Guest molecule size requirements. The host and guest conform to the space matching effect. The size of the cyclodextrin cavity system is different. It is necessary to select the guest molecule that is compatible with the cavity size. The guest molecule is too large to enter the cavity, and the inclusion compound formed if it is too small is unstable.
Hydrophobic and lipophilic interactions between host and guest. Because the cyclodextrin cavity is hydrophobic, the higher the non-polarity of the guest molecule, the easier it is to be included. When the hydrophobic and lipophilic guest molecule enters the cyclodextrin cavity, its hydrophobic group has the greatest contact with the cyclodextrin cavity, while its hydrophilic group is far away from the cavity.
Energy requirements. The formation process of clathrates is accompanied by the change of Gibbs free energy, a relatively large enthalpy change and entropy change, and there is a mutual compensation relationship between the enthalpy change and the entropy change. When the water molecules with high entropy value When removed from the cyclodextrin hole, the internal water molecules cannot form hydrogen bonds and have a high entropy value. When these high-energy water molecules are replaced by suitable guest molecules with a smaller polarity, the energy of the system will be reduce.
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